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M94A2627.TXT
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1994-10-25
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Document 2627
DOCN M94A2627
TI Maternal risk factors in HIV vertical transmission.
DT 9412
AU Maccabruni A; Caselli D; Bossi G; Calderon W; Degioanni M; Gatti M;
Comolli G; Department of Infectious Diseases, IRCCS Policlinico San
Matteo,; Pavia, Italy.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):261 (abstract no. PB0475). Unique
Identifier : AIDSLINE ICA10/94369948
AB Several reports suggest that vertical HIV transmission may be related to
the mother's immunological, virological and clinical status. To
investigate the possible role of these maternal factors we analyzed the
data obtained from 34 HIV seropositive women (20 IVDU and 14
etherosexually infected; 10 multipara) during pregnancy and at delivery
and from their offspring in the years 1991-1993. At delivery HIV p24
Antigen resulted as follows: 21 NEGATIVE; 6 BORDER-LINE CONCENTRATION
(30 pg/ml); 1 50 pg/ml; 3 > = 100 pg/ml; 3 NOT EFFECTED. CD4+ count was
< 200/mmc in 1/10 Ag p24 positive mothers, 300-500/mmc in 6/10 and >
600/mmc in 3/10. All these mothers resulted non transmitting.
Nevertheless two of them had transmitted HIV infection during a previous
pregnancy, when they were Ag p24 negative and clinically asymptomatic.
We demonstrated HIV vertical transmission in 3 mother-child pairs, where
the mothers resulted Ag p24 negative and showed CD4+ count > 400/mmc
during the last trimester of pregnancy and at delivery. Our
retrospective study shows no significant correlation between maternal
immunological and virological parameters and rates of HIV vertical
transmission. Moreover maternal HIV-related symptoms don't seem to be
associated with an highest rate of vertical transmission of infection.
DE AIDS Serodiagnosis Female Human HIV Core Protein p24/BLOOD HIV
Infections/IMMUNOLOGY/*TRANSMISSION Infant, Newborn Leukocyte Count
Pregnancy Pregnancy Complications, Infectious/*DIAGNOSIS/IMMUNOLOGY
Retrospective Studies Risk Factors T4 Lymphocytes/IMMUNOLOGY MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).